In this lesson, students will use simulations to interact with DNA replication in order to explore semi-conservative replication and identify specific enzymes and their roles in replication.

In this lesson, students will:

• Explore how the structure of DNA supports its semi-conservative replication
• Identify the name and function of several key enzymes in DNA replication
• Recognize the function of Okazaki fragments in DNA replication

• Double helix
• Lagging strand
• Polymerase III
• Base pairs
• Primase
• Leading strand
• Polymerase I
• Helicase
• Okazaki Fragments

Using three simulations, students will interact with DNA replication to explore semi-conservative replication and identify specific enzymes and their roles in replication. Assessments are embedded in the activity to engage discussion and gauge learning. A video (optional) is also available to help guide students through the interactive exploration and the concepts within. 

As a result, students will:

• Learn the basic functions of the following DNA replication enzymes: helicase, primase, ligase, polymerase I and III.
• Learn how the double helix reproduces in a semi-conservative fashion
• Learn the role and function of Okazaki fragments in replication of the lagging strand.